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KMID : 0882420040670040421
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Korean Journal of Medicine
2004 Volume.67 No. 4 p.421 ~ p.424
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Occurrence of tuberculous pleurisy associated with infliximab therapy
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Lee Young-Seok
Jung Jae-One
Hong Ji-Hyun
Seo Young-Il
Eom Kwang-Seok
Jang Seung-Hun
Chung Ki-Suck
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Abstract
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Infliximab is a chimeric antibody against tumor necrosis factor-alpha and it can be used in the treatment of ankylosing spondylitis. Tumor necorosis factor-alpha is a potent proinflammatory cytokine and plays a key role in the host response against tuberculosis. Infliximab is known to be effective on active ankylosing spondylitis but it can also cause reactivation of latent tuberculosis. Physicians should screen patients for latent tuberculous infection or disease before prescribing the drug. We experienced a case of tuberculous pleurisy after taking infliximab in a patient suffering from ankylosing spondylitis. We present the case with a review of literature.
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KEYWORD
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TNF-alpha, Infliximab, Tuberculosis
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